Endocrine Abstracts

PANCH tumour (pituitary adenoma with neuronal choristoma), is a very rare form of pituitary pathology composed of a mixed pituitary adenoma/gangliocytoma. We describe a patient with acromegaly who had evidence of GH synthesis in the neuronal component of a PANCH tumour. A 55-year-old woman was found to have facial features of acromegaly, confirmed biochemically: basal GH 13.56 ng/ml, GTT nadir 8.87 ng/ml, and IGF1 raised at 97.2 nmol/l (ref 9–40). Pituitary function was o...

A 31-year-old man without previous medical history presented to his local hospital with one week history of generalised severe headache. Brain CT was reported as negative for acute intracranial pathology. Five weeks later, he re-presented with worsening headache and blurring of vision. Brain CT revealed a large area of hypodensity centred on the left thalamus/basal ganglia and subsequent MRI with contrast showed a medium size pituitary cyst with suprasellar extension and two c...

Introduction: Silent somatotroph Pituitary Neuroendocrine Tumours (PitNETs) are extremely rare (2−3% of surgically treated pituitary tumours) and data on their natural history and outcomes are scarce.Aim: To review systematically the cases of these tumours presenting in our Centre.Patients and methods: Patients with this diagnosis were identified from our Pituitary Registry and clinical/laboratory/imaging data were collected ...